Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis , structural characterization and biological studies of copper complexes with 2 - aminobenzothiazole derivatives
Novel copper complexes of 2-aminobenzothiazole derivatives were synthesized by the condensation of knoevengal condensate acetoacetanilide (obtained from substituted benzaldehydes and acetoacetanilide) and 2-aminobenzothiazole. They were thoroughly characterized by elemental analysis, IR, H-NMR, UV-Vis., molar conductance, magnetic moment and electrochemical studies. The UV-Vis., spectral study ...
متن کاملAn Aerobic Oxidative Coupling Approach for the Synthesis of N-substituted 2-aminobenzothiazole Derivatives using Iron Catalyst
A facile and convenient method was developed for the formation of novel N substituted 2-aminobenzothiazoles via an iron-catalysed condensation of 2-aminobenzothizole with different amines. This method is applicable for a wide range of aliphatic, aromatic and heterocyclic amines furnishing moderate yields of the corresponding products and thus rendering the methodology as a highly eco-friendly, ...
متن کاملCopper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives.
A mild and efficient Cu(2)O-catalyzed domino intramolecular C-N coupling/C-Y (Y = O, S, N) bond formation was successfully achieved. Thus oxazino[3,2-a]indole, thiazino[3,2-a]indole and indolo[2,1-b]quinazoline derivatives were facilely assembled from readily accessible gem-dibromovinyl systems. The protocol is general and practical, affording a variety of the indole-incorporated products in go...
متن کاملA simple, solvent-free four-component domino synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by copper (II) oxide
An eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) ...
متن کامل2-Aminobenzothiazole derivatives: search for new antifungal agents.
A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal activity. In particular, compounds 1n,o, designed on the basis of molecular modeling studies, were the best of the series, showing MIC values of 4-8 μg/mL against Candida albicans, Candida parapsilosis and Candida tropicali...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organic Letters
سال: 2016
ISSN: 1523-7060,1523-7052
DOI: 10.1021/acs.orglett.6b00967